the 4.6/5.4 modular engines are big engines. they're wider (and i think longer, too) than a 460. You'll probably want a 4r100 transmission for it, because like 92B.I.P. said your e4od has the incorrect bellhousing bolt pattern. For the money involved, you'll come out ahead by building a nice 351 and installing it.
Around 06 or so, someone bought a totalled 05 F150 4x4 and put the drivetrain and interior into a 78/79 bronco, but that's the only person that comes to my mind who has actually completed the swap. I'm sure someone around here has a link to it...